WORK PLATFORMS
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4 self sustained, interlinked, mutually soportive, and synergic platforms of integrative work.
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Each work platform is itself a collaboration of all laboratories of our network, bringing together multiple competences.

BEDSIDE TO BENCH AND BACK APPROACH
WP1: SELECTING CLINICALLY RELEVANT MOLECULAR TARGETS OF NEUROPATHIC PAIN
1.1 SENSORY PROFILES IN HUMAN SUBJECTS

SMALL FIBER NEUROPATHY

NEUROMAS

SENSORY PROFILE
1.2 IDENTIFICATION OF MOLECULAR TARGETS
EXPECTED RESULTS:
Correlation between sensory profiles and a set of key molecular targets for WP2.
MOLECULAR BIOLOGY / HISTOLOGY

CONTROL / NEUROPATHY
WP2: SENSORY TRANSDUCTION AND EXCITABILITY CHANGES
2.1 EXPRESSION PROFILE IN PAIN MODELS
2.2 PHARMACOLOGICAL MODULATION

2.3 GENE THERAPY USING AAV VECTORS
EXPECTED RESULTS:
Restore excitation/inhibition balance using pharmacological and gene therapy strategies.

WP3: POST-TRANSLATIONAL MODIFICATIONS IN NEUROPATHIC PAIN
3.1 CDK5 ACTIVITY IN NEUROPATHIC PAIN MODELS

3.2 PHOSPHORYLATION OF CDK5 TARGETS IN NEUROPATHIC PAIN MODELS
EXPECTED RESULTS:
Cdk5 increases peripheral and central pain sensibilization.

WP4: BACK TRANSLATING PRECLINICAL RESULTS TO HUMANS
4.1 ELECTROPHYSIOLOGY FROM HUMAN TISSUES

EX VIVO PREPS

PHARMACOLOGY
4.2 HUMAN SENSORY NEURONS FROM STEM CELLS
EXPECTED RESULTS:
Validation of mouse models findings in human ex-vivo preparations.
