Visceral sensitivity modulation by fecal microbiota transplantation: the active role of gut bacteria in pain persistence.

Patients with inflammatory bowel diseases (IBD) frequently develop chronic visceral hypersensitivity, presenting an important clinical problem given the lack of effective medications.

Previous research has shown that dysbiosis in the gut microbiota could favor the initiation and persistence of visceral pain.

This study showed that fecal microbiota transplantation was successful in counteracting persistent visceral pain in subjects with IBD, highlighting the therapeutic potential of microbiota-targeted interventions for abdominal pain.

Authors

Lucarini, Elena; Di Pilato, Vincenzo; Parisio, Carmen; Micheli, Laura; Toti, Alessandra; Pacini, Alessandra; Bartolucci, Gianluca; Baldi, Simone; Niccolai, Elena; Amedei, Amedeo; Rossolini, Gian Maria; Nicoletti, Claudio; Cryan, John F.; O’Mahony, Siobhain M.; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo.