PAPER OF THE WEEK

Microglia and neuropathic pain recovery

Damage to the nervous system pathologically alters the somatosensory system, which can result in neuropathic pain. Whereas pain development has been well studied, the mechanisms orchestrating pain recovery remain unclear.

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Neurodynamic treatment is beneficial for neuropathic pain

Nerve injuries lead to disability associated with neuropathic pain that usually manifests as mechanical allodynia and hyperalgesia. Neurodynamic treatment, a non-pharmacological procedure, consists of repeated nerve-selective movement protocols. They have been used to reduce pain and disability in patients, although the biological mechanisms remain poorly characterized.

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How does mindfulness meditation reduce pain?

Mindfulness meditation interrupted communication between brain areas involved in processing pain sensations and areas that produce the sense of self. This resulted in reduced pain as individuals lost ownership of the sensation.

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An epigenetic target to reduce neuropathic pain

Neuropathic pain is characterized by symptoms like hyperalgesia, allodynia and/or spontaneous pain, affecting 7-8% people worldwide. Such symptoms are closely related to changes in the electric properties of sensory neurons secondary to peripheral nerve damage. One of these mechanisms involves reducing the levels of voltage-gated potassium channels.

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Microglia-independent peripheral neuropathic pain

Neuropathic pain arises as a direct consequence of a lesion or disease of the somatosensory system. A hallmark of neuropathic pain is the proliferation, morphological changes and activation of microglia in the spinal dorsal horn. Salter and cols discovered a form of neuropathic pain that is independent of microglia. Nucleus pulposus secrete soluble factor which recruit macrophages into the sciatic nerve where they release BDNF which induce pain hypersensitivity. These findings help to explain the limited success of microglial inhibitors on neuropathic pain in human clinical trials.

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Is it important to study pain in Parkinson’s disease?

Parkinson’s Disease (PD) has traditionally been considered a neurodegenerative disease with motor involvement associated with the accumulation and misfolding of the protein alpha-synuclein (aSyn). However, non-motor symptoms such as thermal and mechanical sensory dysfunction, as well as a considerable decrease in intraepidermal nerve fibers, are becoming more important in these patients; It remains unclear how aSyn misfolding could affect these symptoms.

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Emotional imbalances caused by chronic pain

It is well known that chronic pain states in humans may generate complex emotional imbalances. Many studies have shown that chronic pain indeed causes negative emotions and common pathologies, such as anxiety and depression. However, how chronic pain produces anxiety and depression at the brain level is unknown.

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A novel mechanism for chronic pain regulation

According to the authors, the enzyme PDI (Protein Dithiol Isomerase) would be a novel participant in chronic pain regulation, activating TRPV1 allosterically (ligand-independent), which would lead to heat hyperalgesia (increase pain in response to noxious heat).

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Chairs: Margarita Calvo, MD, PhD.
Speaker: Margarita Calvo
Location: Conferencia Internacional del Peripheral Nerve Society 2021
Neuropathic Pain Mind-Changers – Breaking News from Basic and Clinical Science
Speaker: Margarita Calvo
Location: Congreso Mundial del Dolor IASP 2021
Canales de iones y lágrimas
Speaker: Rodolfo Madrid
Location: Facultad de Medicina UCN
Entrevista a RM en el programa All you need is Lab
Speaker: Rodolfo Madrid
Location: Radio & TV USACH
Curso de actualización “Efecto de Fármacos y Drogas en el funcionamiento del Sistema Nervioso” Baw Concepción
Speaker: Gonzalo Yévenes
Location: Ciclo de charlas de actualización para profesores de enseñanza media, Servicio local de Educación Andalien Sur, Concepción
Participación de la quinasa Cdk5 en la sensibilización periférica durante el dolor orofacial
Speaker: Elías Utreras
Location: Centro de Investigación e Innovación Biomédica (CIIB) de la Universidad de los Andes
Función de la quinasa Cdk5 en sensibilización periférica durante el dolor inflamatorio orofacial
Speaker: Elías Utreras
Location: VII Jornada de Kinesiología maxilofacial 2021
Neurotransmisión inhibitoria y dolor crónico
Speaker: Gonzalo Yévenes
Location Seminario científico Departamento de Ciencias Biomédicas
Webinar "Dolor Neuropático Oncológico
Speaker: Margarita Calvo

Location: Comité Internacional de Mujeres en Neuromodulación de la Sociedad Argentina de Neuromodulación (SANE)

Asociación Chilena del estudio del dolor (ACHED)
Speaker: Margarita Calvo
Location: Asociación Chilena del estudio del dolor (ACHED).
Quinasa Cdk5 y Dolor Facial
Speaker: Elías Utreras
Location: Conferencias Núcleo Milenio para el estudio del dolor
Role of Kv1.6 channel in blocking hyperexcitability after nerve injury
Speaaker: Margarita Calvo
Location: XVI reunión de la Sociedad de Neurociencias
Glycine receptor modulation in chronic pain
Speaker: Gonzalo Yévenes
Location XVI reunión de la Sociedad de Neurociencias
Regulation of the P2X2 receptor channel by calcium and phosphorylation and its potential role on pain signaling
Speaker: Claudio Coddou
Location: XVI reunión de la Sociedad de Neurociencias
Simposio Exploring key molecular determinants in pain neurophysiology
Speaker: Rodolfo Madrid y Elías Utreras
Location XVI reunión de la Sociedad de Neurociencias
Simposio Exploring key molecular determinants in pain neurophysiology
Speaker: Elías Utreras
Location: El papel del ejercicio en el manejo del dolor