PAPER OF THE WEEK
Salivary Endocannabinoid Profiles in Chronic Orofacial Pain and Headache Disorders
In this paper, they evaluated the specific salivary endocannabinoids in individuals with different types of OFP.
Are there gender-dependent differences in how chronic pain affects people?
A classic and very colloquial question is whether the tolerance and/or perception of pain is
different in people of different gender, age, or psychological condition. Preclinical studies have
shown that chronic pain can be different in intensity and duration depending on these factors.
Non-deceptive placebos have analgesic effects regulated by endogenous opioids
It’s been reported that placebo effect can be induced without the need for deceiving the patient, but rather simply the act of performing the procedure while explaining that it’s fake (Kaptchunk, 2018) which would hugely facilitate their use in clinical trials.
Microglia and neuropathic pain recovery
Damage to the nervous system pathologically alters the somatosensory system, which can result in neuropathic pain. Whereas pain development has been well studied, the mechanisms orchestrating pain recovery remain unclear.
What is Allodynia and which neurons are responsible for its propagation?
The authors of this study were able to identify neuronal groups in the spinal cord involved in this sensitization process. For this, they used a molecule from chili peppers called capsaicin, applied to the skin resulting in allodynia that extends to a broad region beyond the application site.
Visceral sensitivity modulation by fecal microbiota transplantation
Patients with inflammatory bowel diseases (IBD) frequently develop chronic visceral hypersensitivity, presenting an important clinical problem given the lack of effective medications.
An analgesic peptide H-20 attenuates chronic pain via the PD-1 pathway with few adverse effects
The lack of effective and safe analgesics to treat chronic pain is a health problem that diminish the life quality of people who suffers this illness.
Neurodynamic treatment is beneficial for neuropathic pain
Nerve injuries lead to disability associated with neuropathic pain that usually manifests as mechanical allodynia and hyperalgesia. Neurodynamic treatment, a non-pharmacological procedure, consists of repeated nerve-selective movement protocols. They have been used to reduce pain and disability in patients, although the biological mechanisms remain poorly characterized.
New secretory pathway controls axonal trafficking of the TRPM8 channel
In 2020, investigators from MinusPain identified the presence of a non-conventional secretory pathway composed by endoplasmic reticulum, Golgi apparatus and exocytic vesicles markers in peripheral axons from sciatic nerve.
How does mindfulness meditation reduce pain?
Mindfulness meditation interrupted communication between brain areas involved in processing pain sensations and areas that produce the sense of self. This resulted in reduced pain as individuals lost ownership of the sensation.
The acquisition of cold sensitivity during TRPM8 ion channel evolution
On these freezing days, the function of the TRPM8 channel, the main cold transducer in the somatosensory system, becomes relevant.
Can touch from your romantic partner reduce pain?
Interpersonal touch is associated with well-being and pleasant emotions, but can touch from your
romantic partner reduce pain?
NSAIDs usage may increase the odds of developing chronic pain by impairing natural recovery processes on acute pain episodes
My back hurts a lot from sitting all day… Do I take an Ibuprofen or a Paracetamol pill? Parisien et al. suggest not to take the decision lightly.
Neuropathic pain caused by miswiring and abnormal end organ targeting
This paper describes a remarkable link between reinnervation after peripheral nerve damage and painful hypersensitivity to gentle touch or mechanical allodynia.
An epigenetic target to reduce neuropathic pain
Neuropathic pain is characterized by symptoms like hyperalgesia, allodynia and/or spontaneous pain, affecting 7-8% people worldwide. Such symptoms are closely related to changes in the electric properties of sensory neurons secondary to peripheral nerve damage. One of these mechanisms involves reducing the levels of voltage-gated potassium channels.
Role of the unsaturated fatty Docosahexaenoic acid in the central nervous system: molecular and cellular insights.
Fatty acids are essential components of the nervous system. Within the fatty acids, it is the DHA, a key molecule for the neurons functions.
Microglia-independent peripheral neuropathic pain
Neuropathic pain arises as a direct consequence of a lesion or disease of the somatosensory system. A hallmark of neuropathic pain is the proliferation, morphological changes and activation of microglia in the spinal dorsal horn. Salter and cols discovered a form of neuropathic pain that is independent of microglia. Nucleus pulposus secrete soluble factor which recruit macrophages into the sciatic nerve where they release BDNF which induce pain hypersensitivity. These findings help to explain the limited success of microglial inhibitors on neuropathic pain in human clinical trials.
Is it important to study pain in Parkinson’s disease?
Parkinson’s Disease (PD) has traditionally been considered a neurodegenerative disease with motor involvement associated with the accumulation and misfolding of the protein alpha-synuclein (aSyn). However, non-motor symptoms such as thermal and mechanical sensory dysfunction, as well as a considerable decrease in intraepidermal nerve fibers, are becoming more important in these patients; It remains unclear how aSyn misfolding could affect these symptoms.
Emotional imbalances caused by chronic pain
It is well known that chronic pain states in humans may generate complex emotional imbalances. Many studies have shown that chronic pain indeed causes negative emotions and common pathologies, such as anxiety and depression. However, how chronic pain produces anxiety and depression at the brain level is unknown.
A novel mechanism for chronic pain regulation
According to the authors, the enzyme PDI (Protein Dithiol Isomerase) would be a novel participant in chronic pain regulation, activating TRPV1 allosterically (ligand-independent), which would lead to heat hyperalgesia (increase pain in response to noxious heat).
Chairs: Margarita Calvo, MD, PhD.
Neuropathic Pain Mind-Changers – Breaking News from Basic and Clinical Science
Canales de iones y lágrimas
Entrevista a RM en el programa All you need is Lab
Curso de actualización “Efecto de Fármacos y Drogas en el funcionamiento del Sistema Nervioso” Baw Concepción
Participación de la quinasa Cdk5 en la sensibilización periférica durante el dolor orofacial
Función de la quinasa Cdk5 en sensibilización periférica durante el dolor inflamatorio orofacial
Neurotransmisión inhibitoria y dolor crónico
Webinar "Dolor Neuropático Oncológico
Location: Comité Internacional de Mujeres en Neuromodulación de la Sociedad Argentina de Neuromodulación (SANE)