MINUS PAIN

TRANSLATIONAL PAIN RESEARCH

A CULTURED SPINAL CORD NEURON. NUCLEAR (BLUE), CYTOSKELETON (RED) AND GLYCINE RECEPTOR (GREEN) INMUNOSTAININGS ARE SHOWN. (CREDIT. NEUROPHARMACOLOGY LAB, UDEC)

PATCH-CLAMP RECORDING SETUP AND ACTIVATION OF LIGHT-SENSITIVE PROTEINS USING 470 NM ILLUMINATION

RESEARCHERS

5 Principal Investigators, 2 Adjunct Investigators, 2 International Senior Members, 2 Junior Investigators

TWITTER

A partir de hoy, y hasta el 03 de diciembre, se realizará el XLII Congreso Anual de la Sociedad de Farmacología de Chile (SOFARCHI) que contará con conferencistas de primer nivel.

El objetivo de esta actividad es potenciar y abrir la farmacología al ámbito clínico 👇

Nuestro Director Alterno, @utrerase, participó del programa "Imago Mundi" de @canal2chilenafm para hablar del #dolor, sus investigaciones y avances ligados a este tema junto a Luis Valderas 😉

Revisa la entrevista completa aquí 👇

https://www.youtube.com/watch?v=gFP1tC1EESE&ab_channel=MiNuSPain

#CentrosAnid #Ciencia

Desde hace mucho tiempo, en la comunidad científica ha estudiado la fisiología de las neuronas que detectan el calor, el frío, los estímulos mecánicos como el tacto suave, y los estímulos químicos y físicos potencialmente peligrosos o nocivos 👇

MILLENNIUM NUCLEUS FOR THE STUDY OF PAIN

We are a scientific consortium dedicated to investigate in translational neuroscience of pain. We aim at training advanced human capital in scientific and clinical area.

 

Our Millennium Nucleus MiNuSPain includes five research laboratories whose competences range from cutting-edge biomedical research to clinical studies. MiNusPain collaborations are reflected in associative projects, publications, international conferences and co-supervision of trainees.

Our work has a translational approach from the bedside to the bench and back, a concept that illustrates the path along which our lines of research progress collaboratively, ranging from biomedical science to patients. We are focused on investigating key molecular determinants involved in neuropathic pain. In particular, we will focus on the study of cellular and molecular mechanisms in preclinical and clinical models.

Photomicroscopy of a skin sample showing C fibres crossing toward the epidermis (PGP9.5 in red, DAPI in blue)

WHAT IS NEUROPHATIC PAIN?

It is defined as pain caused by an illness that affects the somatosensory nervous system.

 

Neuropathic pain affects about 7 to 10% of the world population. Neuropathic pain is disabling and produces a great socioeconomic cost. Therefore, it has become a priority public health problem.

Currently, treatments for neuropathic pain are poorly tolerated and their efficacy is poor. The opioid epidemic has shown us that the effect of long term use of these medications can be a real problem. A better understanding of the cellular and molecular bases of neuropathic pain will provide fundamental keys to recognize new pharmacological targets for treatment.

Photomicroscopy of a spinal ganglion growing in vitro (credit: Paula Diaz). 4th place Contest Nikon Small World

RESEARCH TARGETS

We will focus on the unbalance of excitatory and inhibitory molecular entities underlying altered sensory transduction and excitability of sensory neurons, as key determinants of neuropathic pain.

GENERAL OUTREACH

FIRST EXHIBITION OF TALKS ON PAIN AND FIBROMYALGIA CYCLE

FIRST EXHIBITION OF TALKS ON PAIN AND FIBROMYALGIA CYCLE

SECOND EXHIBITION OF TALKS ON PAIN AND FIBROMYALGIA CYCLE, ORGANIZED BY THE MILLENIUM NUCLEUS MINUS PAIN

SECOND EXHIBITION OF TALKS ON PAIN AND FIBROMYALGIA CYCLE, ORGANIZED BY THE MILLENIUM NUCLEUS MINUS PAIN

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1° Ciclo de Charlas sobre Dolor y Fibromialgia
Speaker: Gonzalo Yévenes
Location: Ciclo de charlas virtuales sobre Dolor y Fibromialgia organizado por Minus Pain
1° Ciclo de Charlas sobre Dolor y Fibromialgia "Rol de la alimentación en el manejo del dolor"
Speaker: Rodolfo Madrid
Location: Ciclo de charlas virtuales sobre Dolor y Fibromialgia organizado por Minus Pain
1° Ciclo de Charlas sobre Dolor y Fibromialgia “Rol de la psicología en el dolor"
Speaker: Claudio Coddou
Location: Ciclo de charlas virtuales sobre Dolor y Fibromialgia  organizado por Minus Pain

SCIENTIFIC OUTREACH

Chairs: Margarita Calvo, MD, PhD.
Speaker: Margarita Calvo
Location: Conferencia Internacional del Peripheral Nerve Society 2021
Neuropathic Pain Mind-Changers – Breaking News from Basic and Clinical Science
Speaker: Margarita Calvo
Location: Congreso Mundial del Dolor IASP 2021
Canales de iones y lágrimas
Speaker: Rodolfo Madrid
Location: Facultad de Medicina UCN