MINUS PAIN

TRANSLATIONAL PAIN RESEARCH

A CULTURED SPINAL CORD NEURON. NUCLEAR (BLUE), CYTOSKELETON (RED) AND GLYCINE RECEPTOR (GREEN) INMUNOSTAININGS ARE SHOWN. (CREDIT. NEUROPHARMACOLOGY LAB, UDEC)

PATCH-CLAMP RECORDING SETUP AND ACTIVATION OF LIGHT-SENSITIVE PROTEINS USING 470 NM ILLUMINATION

RESEARCHERS

5 Principal Investigators, 2 Adjunct Investigators, 2 International Senior Members, 2 Junior Investigators

TWITTER

En #MiNuSPain investigamos las bases celulares y moleculares implicadas en todos los procesos que están relacionados con la sensación de dolor. Nos interesa, específicamente, estudiar el dolor crónico y en particular el dolor neuropático.

Que maravilloso que exista un centro ocupándose de este gran y complejo problema ¡Me encanta! https://twitter.com/minuspain/status/1447986875898150913

Un diez por ciento del gasto completo en salud en Chile se destina a aliviar el dolor crónico, lo que equivale a lo que el país invierte en investigación en total. De ahí que entender los mecanismos que producen el dolor, para poder disminuirlo o prevenirlo, resulta clave 👇

MILLENNIUM NUCLEUS FOR THE STUDY OF PAIN

We are a scientific consortium dedicated to investigate in translational neuroscience of pain. We aim at training advanced human capital in scientific and clinical area.

 

Our Millennium Nucleus MiNuSPain includes five research laboratories whose competences range from cutting-edge biomedical research to clinical studies. MiNusPain collaborations are reflected in associative projects, publications, international conferences and co-supervision of trainees.

Our work has a translational approach from the bedside to the bench and back, a concept that illustrates the path along which our lines of research progress collaboratively, ranging from biomedical science to patients. We are focused on investigating key molecular determinants involved in neuropathic pain. In particular, we will focus on the study of cellular and molecular mechanisms in preclinical and clinical models.

Photomicroscopy of a skin sample showing C fibres crossing toward the epidermis (PGP9.5 in red, DAPI in blue)

WHAT IS NEUROPHATIC PAIN?

It is defined as pain caused by an illness that affects the somatosensory nervous system.

 

Neuropathic pain affects about 7 to 10% of the world population. Neuropathic pain is disabling and produces a great socioeconomic cost. Therefore, it has become a priority public health problem.

Currently, treatments for neuropathic pain are poorly tolerated and their efficacy is poor. The opioid epidemic has shown us that the effect of long term use of these medications can be a real problem. A better understanding of the cellular and molecular bases of neuropathic pain will provide fundamental keys to recognize new pharmacological targets for treatment.

Photomicroscopy of a spinal ganglion growing in vitro (credit: Paula Diaz). 4th place Contest Nikon Small World

RESEARCH TARGETS

We will focus on the unbalance of excitatory and inhibitory molecular entities underlying altered sensory transduction and excitability of sensory neurons, as key determinants of neuropathic pain.

GENERAL OUTREACH

FIRST EXHIBITION OF TALKS ON PAIN AND FIBROMYALGIA CYCLE

The activity counted with Dr. Margarita Calvo’s participation, surgeon at the Pontificia Universidad Católica of Chile, member of the Pain Unit in the UC Christus Health Network (Chile), Associate Professor of the Faculty of Biological Sciences at Pontificia Universidad Católica of Chile and Director of the Millennium Nucleus MiNuSPain.

SECOND EXHIBITION OF TALKS ON PAIN AND FIBROMYALGIA CYCLE, ORGANIZED BY THE MILLENIUM NUCLEUS MINUS PAIN

The activity was presented by Fernanda Tumani, nutritionist at the UC Christus Network and Dr. Rodolfo Madrid, Associate Researcher at the Millennium Nucleus MiNuSPain, Associate Researcher at the Millennium Nucleus MiNICAD and Associate Professor at the Universidad de Santiago de Chile.
1° Ciclo de Charlas sobre Dolor y Fibromialgia
Speaker: Gonzalo Yévenes
Location: Ciclo de charlas virtuales sobre Dolor y Fibromialgia organizado por Minus Pain
1° Ciclo de Charlas sobre Dolor y Fibromialgia "Rol de la alimentación en el manejo del dolor"
Speaker: Rodolfo Madrid
Location: Ciclo de charlas virtuales sobre Dolor y Fibromialgia organizado por Minus Pain
1° Ciclo de Charlas sobre Dolor y Fibromialgia “Rol de la psicología en el dolor"
Speaker: Claudio Coddou
Location: Ciclo de charlas virtuales sobre Dolor y Fibromialgia  organizado por Minus Pain

FIBRIOMYALGIA CAPSULES

SCIENTIFIC OUTREACH

Chairs: Margarita Calvo, MD, PhD.
Speaker: Margarita Calvo
Location: Conferencia Internacional del Peripheral Nerve Society 2021
Neuropathic Pain Mind-Changers – Breaking News from Basic and Clinical Science
Speaker: Margarita Calvo
Location: Congreso Mundial del Dolor IASP 2021
Canales de iones y lágrimas
Speaker: Rodolfo Madrid
Location: Facultad de Medicina UCN
Entrevista a RM en el programa All you need is Lab
Speaker: Rodolfo Madrid
Location: Radio & TV USACH
Curso de actualización “Efecto de Fármacos y Drogas en el funcionamiento del Sistema Nervioso” Baw Concepción
Speaker: Gonzalo Yévenes
Location: Ciclo de charlas de actualización para profesores de enseñanza media, Servicio local de Educación Andalien Sur, Concepción
Participación de la quinasa Cdk5 en la sensibilización periférica durante el dolor orofacial
Speaker: Elías Utreras
Location: Centro de Investigación e Innovación Biomédica (CIIB) de la Universidad de los Andes
Función de la quinasa Cdk5 en sensibilización periférica durante el dolor inflamatorio orofacial
Speaker: Elías Utreras
Location: VII Jornada de Kinesiología maxilofacial 2021
Neurotransmisión inhibitoria y dolor crónico
Speaker: Gonzalo Yévenes
Location: Seminario científico Departamento de Ciencias Biomédicas
Webinar "Dolor Neuropático Oncológico
Speaker: Margarita Calvo

Location: Comité Internacional de Mujeres en Neuromodulación de la Sociedad Argentina de Neuromodulación (SANE)

Asociación Chilena del estudio del dolor (ACHED)
Speaker: Margarita Calvo
Location: Asociación Chilena del estudio del dolor (ACHED).
Quinasa Cdk5 y Dolor Facial
Speaker: Elías Utreras
Location: Conferencias Núcleo Milenio para el estudio del dolor
Role of Kv1.6 channel in blocking hyperexcitability after nerve injury
Speaker: Margarita Calvo
Location: XVI reunión de la Sociedad de Neurociencias
Glycine receptor modulation in chronic pain
Speaker: Gonzalo Yévenes
Location: XVI reunión de la Sociedad de Neurociencias
Regulation of the P2X2 receptor channel by calcium and phosphorylation and its potential role on pain signaling
Speaker: Claudio Coddou
Location: XVI reunión de la Sociedad de Neurociencias
Simposio Exploring key molecular determinants in pain neurophysiology
Speaker: Rodolfo Madrid y Elías Utreras
Location: XVI reunión de la Sociedad de Neurociencias
Simposio Exploring key molecular determinants in pain neurophysiology
Speaker: Elías Utreras
Location: El papel del ejercicio en el manejo del dolor