MINUS PAIN

TRANSLATIONAL PAIN RESEARCH

A CULTURED SPINAL CORD NEURON. NUCLEAR (BLUE), CYTOSKELETON (RED) AND GLYCINE RECEPTOR (GREEN) INMUNOSTAININGS ARE SHOWN. (CREDIT. NEUROPHARMACOLOGY LAB, UDEC)

PATCH-CLAMP RECORDING SETUP AND ACTIVATION OF LIGHT-SENSITIVE PROTEINS USING 470 NM ILLUMINATION

CHECK OUT THE FEATURED PAPER OF THE WEEK

RESEARCHERS

5 Principal Investigators, 2 Adjunct Investigators, 2 International Senior Members, 2 Junior Investigators

TWITTER

Over 10% of Chile's health care budget goes on treating chronic #pain, which is the equivalent of the country's total yearly research investment. Understanding how pain is caused is key to reducing it. Learn about the #MiNuSPain project, led by UC Chile:
▶️https://bit.ly/3FvaE9X

La fotografía de nuestra estudiante de doctorado, Paula Díaz, fue considerada dentro de las MEJORES IMÁGENES CIENTÍFICAS DEL AÑO 2021 por la renombrada revista NATURE.
Contar con estudiantes de este nivel es un orgullo para nuestro centro.

https://www.nature.com/immersive/d41586-021-03521-3/index.html?utm_source=insta_nat&utm_medium=social&utm_campaign=nature&utm_content=later-23606438

¿Cómo hacer para que lo digital sea una herramienta que rompa el orden de género binario? 🤔 Súmate a #Digitalizadas para #HackearLoBinario el próximo 21 de enero en #CongresoFuturo2022 Entérate de todo acá https://congresofuturo.cl/digitalizadas-2022/

MILLENNIUM NUCLEUS FOR THE STUDY OF PAIN

We are a scientific consortium dedicated to investigate in translational neuroscience of pain. We aim at training advanced human capital in scientific and clinical area.

 

Our Millennium Nucleus MiNuSPain includes five research laboratories whose competences range from cutting-edge biomedical research to clinical studies. MiNusPain collaborations are reflected in associative projects, publications, international conferences and co-supervision of trainees.

Our work has a translational approach from the bedside to the bench and back, a concept that illustrates the path along which our lines of research progress collaboratively, ranging from biomedical science to patients. We are focused on investigating key molecular determinants involved in neuropathic pain. In particular, we will focus on the study of cellular and molecular mechanisms in preclinical and clinical models.

Photomicroscopy of a skin sample showing C fibres crossing toward the epidermis (PGP9.5 in red, DAPI in blue)

WHAT IS NEUROPHATIC PAIN?

It is defined as pain caused by an illness that affects the somatosensory nervous system.

 

Neuropathic pain affects about 7 to 10% of the world population. Neuropathic pain is disabling and produces a great socioeconomic cost. Therefore, it has become a priority public health problem.

Currently, treatments for neuropathic pain are poorly tolerated and their efficacy is poor. The opioid epidemic has shown us that the effect of long term use of these medications can be a real problem. A better understanding of the cellular and molecular bases of neuropathic pain will provide fundamental keys to recognize new pharmacological targets for treatment.

Photomicroscopy of a spinal ganglion growing in vitro (credit: Paula Diaz). 4th place Contest Nikon Small World

RESEARCH TARGETS

We will focus on the unbalance of excitatory and inhibitory molecular entities underlying altered sensory transduction and excitability of sensory neurons, as key determinants of neuropathic pain.

GENERAL OUTREACH

FIRST EXHIBITION OF TALKS ON PAIN AND FIBROMYALGIA CYCLE

FIRST EXHIBITION OF TALKS ON PAIN AND FIBROMYALGIA CYCLE

SECOND EXHIBITION OF TALKS ON PAIN AND FIBROMYALGIA CYCLE, ORGANIZED BY THE MILLENIUM NUCLEUS MINUS PAIN

SECOND EXHIBITION OF TALKS ON PAIN AND FIBROMYALGIA CYCLE, ORGANIZED BY THE MILLENIUM NUCLEUS MINUS PAIN

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1° Ciclo de Charlas sobre Dolor y Fibromialgia
Speaker: Gonzalo Yévenes
Location: Ciclo de charlas virtuales sobre Dolor y Fibromialgia organizado por Minus Pain
1° Ciclo de Charlas sobre Dolor y Fibromialgia "Rol de la alimentación en el manejo del dolor"
Speaker: Rodolfo Madrid
Location: Ciclo de charlas virtuales sobre Dolor y Fibromialgia organizado por Minus Pain
1° Ciclo de Charlas sobre Dolor y Fibromialgia “Rol de la psicología en el dolor"
Speaker: Claudio Coddou
Location: Ciclo de charlas virtuales sobre Dolor y Fibromialgia  organizado por Minus Pain