FEATURED PAPERS

12/21/2021

Capsaicin-induced depolymerization of axonal microtubules mediates analgesia for trigeminal neuropathic pain

The article presents the investigation of nociceptors expressed in sensory neurons, specifically the TRPV1 ion channel. This protein is responsible for sensing temperature changes in the skin, specifically high temperatures that could cause tissue damage. However, this article presents the novel research that this channel could be activated by bacterial metabolites present in our system.

Featured Authors:

Chung S, Kim H, Kim D, Lee J M, Lee C J, Oh S B

12/13/2021

Combining topical agonists with the recording of event-related brain potentials to probe the functional involvement of TRPM8, TRPA1 and TRPV1 in heat and cold transduction in the human skin

TRP channels play a central role in the transduction of thermal and nociceptive stimuli by free nerve endings. Most of the research on these channels has been conducted in vitro or in vivo in non-human animals and translation of these results to humans must account for potential experimental biases and interspecific differences. This study aimed at evaluating the involvement of TRPM8 (Menthol), TRPA1 (Cinnamaldehyde) and TRPV1 (Capsaicin) channels in the transduction of heat and cold stimuli by the human thermonociceptive system.

Featured Authors:

Arthur S. Courtin & André Mouraux

11/06/2021

Association of Genetic Variant at Chromosome 12q23.1 With Neuropathic Pain Susceptibility

The ability to detect external noxious stimuli and signals from internal organs is essential to maintain physical integrity and homeostasis. This process is mediated by nociceptors, which recognize stimuli through specialized receptors. The perception of nociceptive pain depends on the continuity of the sensory fibers of the peripheral nerve, which is why functional humanized in vitro nerve models are coveted as an alternative to animal models due to their ease of access, lower cost, clinical relevance and the no need for recurring animal sacrifices. To this end, a sensory nerve model was developed using induced pluripotent stem cell (iPSC) derived nociceptors that are electrically active and exhibit a functional response to noxious stimuli.

Featured Authors:

Veluchamy A, Hébert HL, van Zuydam NR, Pearson ER, Campbell A, Hayward C, Meng W, McCarthy MI, Bennett DLH, Palmer CNA, Smith BH

11/29/2021

Capsaicin-induced depolymerization of axonal microtubules mediates analgesia for trigeminal neuropathic pain

This research suggests that capsaicin increases microtubule depolymerization, which induces axonal ablation and, therefore, mediates analgesia for neuropathic pain of the trigeminal nerve. To test their hypothesis, the researchers studied the effects of microtubule stabilization on capsaicin-induced axonal ablation, and analgesia for trigeminal neuropathic pain in mice.

Featured Authors:

Arora, Vipina; Li, Tingtinga; Kumari, Sinua; Wang, Shenga; Asgar, Jamilaa; Chung, Man-Kyoa

11/22/2021

3D culture platform of human iPSCs-derived nociceptors for peripheral nerve modelling and tissue innervation

TRP channels play a central role in the transduction of thermal and nociceptive stimuli by free nerve endings. Most of the research on these channels has been conducted in vitro or in vivo in non-human animals and translation of these results to humans must account for potential experimental biases and interspecific differences. This study aimed at evaluating the involvement of TRPM8 (Menthol), TRPA1 (Cinnamaldehyde) and TRPV1 (Capsaicin) channels in the transduction of heat and cold stimuli by the human thermonociceptive system.

Featured Authors:

Afonso Malheiro 1, Abhishek Harichandan 2, Joyce Bernardi 3, Adrián Seijas-Gamardo 1, Gonda F Konings 4, Paul G A Volders 3, Andrea Romano 4, Carlos Mota 5, Paul Wieringa 6, Lorenzo Moroni 7